Date of Award
4-2006
Degree Name
Doctor of Philosophy
Department
Statistics
Abstract
This research gives methods for sequential monitoring of survival data in clinical trials with multiple endpoints. We illustrate the use of marginal proportional hazards models and other survival models with various group sequential methods to test multiple survival endpoints at K interim analyses. To adjust for multiplicity at each interim analysis, we consider and extend methods developed by Tang and Geller (1999), Follmann, et al. (1994), and others. These methods are motivated, compared, and evaluated using survival data from a clinical study and using simulation studies.
Access Setting
Dissertation-Open Access
Recommended Citation
Scherzer, Rebecca C., "Testing Procedures for Group Sequential Clinical Trials with Multiple Survival Endpoints" (2006). Dissertations. 985.
https://scholarworks.wmich.edu/dissertations/985