Date of Defense



Biological Sciences

First Advisor

David Cowan, Biological Sciences

Second Advisor

James Kiddle, Chemistry

Third Advisor

William Theodore, National Institute of Neurological Disorders and Stroke


The question of whether brief seizures cause brain damage has been a focus of study for researchers over the last several years. This study focused on hippocampal atrophy in children with TLE. The authors analyzed the serial MRIs of 7 patients and used volumetric analysis to determine the extent or presence of hippocampal atrophy. Results indicated a non-significant trend towards hippocampal atrophy over time on the side of seizure focus. Implications for future research and trends are discussed.

Access Setting

Honors Thesis-Campus Only