Date of Defense

4-25-2005

Department

Chemistry

First Advisor

James Kiddle, Department of Chemistry

Second Advisor

Susan R. Stapleton, Department of Chemistry

Third Advisor

Yirong Mo, Department of Chemistry

Keywords

Neuropathic compounds, tyrosine, tyrosine residues, protein tyrosine kinases

Abstract

In the present study, we investigate the reactivity of tyrosine with simulants of neuropathic organophosphates as a potential explanation of organophosphate induced delayed neuropathy (OPIDN). We have found that these organophosphates are extremely reactive toward substitution by tyrosine. This suggests that it is possible for these neuropathic compounds to react with tyrosine residues in proteins, including tyrosine residues in protein tyrosine kinases. This could dramatically effect signal transduction pathways in the cell, and suggest an additional target involved in OPIDN.

Access Setting

Honors Thesis-Campus Only

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