Date of Defense
James Kiddle, Department of Chemistry
Susan R. Stapleton, Department of Chemistry
Yirong Mo, Department of Chemistry
Neuropathic compounds, tyrosine, tyrosine residues, protein tyrosine kinases
In the present study, we investigate the reactivity of tyrosine with simulants of neuropathic organophosphates as a potential explanation of organophosphate induced delayed neuropathy (OPIDN). We have found that these organophosphates are extremely reactive toward substitution by tyrosine. This suggests that it is possible for these neuropathic compounds to react with tyrosine residues in proteins, including tyrosine residues in protein tyrosine kinases. This could dramatically effect signal transduction pathways in the cell, and suggest an additional target involved in OPIDN.
Clift, Michael, "Alternative Explanation of Organophosphate Induced Delayed Neuropathy" (2005). Honors Theses. 704.
Honors Thesis-Campus Only