Date of Defense

4-25-2000

Department

Chemistry

First Advisor

Susan Stapleton, Chemistry

Second Advisor

Steve Bertman, Chemistry

Third Advisor

Michael McCarville, Chemistry

Keywords

Solid-phase synthesis, heterocyclic ring systems, drug discovery, cross-coupling reactions

Abstract

The solid-phase synthesis of heterocyclic ring systems of importance to drug discovery is an active area of research. The 2,6-bisarylpyridines have been explored as platforms for the discovery of antimalaria and antihypertensive agents, and for use as starting materials for a variety of macrocycles and combinatorial library productions. The palladium-catalyzed cross-coupling reactions offer a convenient, versatile synthetic method for the formation of a carbon-carbon bond. Implementation of the cross-coupling reactions of organotin and organoboronic acid reagents will be utilized in the preparation of 2,6-bisarylpyridines.

Access Setting

Honors Thesis-Campus Only

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