Date of Defense
Susan Stapleton, Chemistry
Steve Bertman, Chemistry
Michael McCarville, Chemistry
Solid-phase synthesis, heterocyclic ring systems, drug discovery, cross-coupling reactions
The solid-phase synthesis of heterocyclic ring systems of importance to drug discovery is an active area of research. The 2,6-bisarylpyridines have been explored as platforms for the discovery of antimalaria and antihypertensive agents, and for use as starting materials for a variety of macrocycles and combinatorial library productions. The palladium-catalyzed cross-coupling reactions offer a convenient, versatile synthetic method for the formation of a carbon-carbon bond. Implementation of the cross-coupling reactions of organotin and organoboronic acid reagents will be utilized in the preparation of 2,6-bisarylpyridines.
Dishinger, Brian, "Aryl-aryl Bond Forming Reactions for the Preparation of 2,6-bisarylpyridines" (2000). Honors Theses. 707.
Honors Thesis-Campus Only