Date of Award
6-1988
Degree Name
Master of Arts
Department
Psychology
Access Setting
Masters Thesis-Open Access
Abstract
After initial exposure to 80 mg/kg ethosuximide, pigeons trained in a two-key drug discrimination procedure rapidly learned to discriminate 120 mg/kg ethosuximide from saline. When 40 to 160 mg/kg doses of ethosuximide were administered during generalization tests, the percentage of the responses directed to the ethosuximide-appropriate key varied directly with dose. Time-effect determinations revealed that the discriminable properties of ethosuximide were evident as early as 15 min after, and as late as 2 hrs after, intramuscular injection. The discriminative stimulus properties of ethosuximide failed to generalize to the anticonvulsant compounds clonazepam (0.5-4 mg/kg), methsuximide (25-200 mg/kg), and phenytoin (5-15 mg/kg). Generalization was apparent with certain doses of primidone (250, 300 mg/kg) and mepheytoin (80, 160, 240 mg/kg). The concomittant administration of pentylenetetrazol (5, 10, 20 mg/kg) partially blocked the discriminable properties of the training dose of the ethosuximide.
Recommended Citation
Clark, Rodney D., "The Discriminative Stimulus Properties of Ethosuximide in the Pigeon" (1988). Masters Theses. 1154.
https://scholarworks.wmich.edu/masters_theses/1154