Date of Award
4-2013
Degree Name
Master of Science
Department
Chemistry
First Advisor
Dr. Susan R. Stapleton
Second Advisor
Dr. David Huffman
Third Advisor
Dr. Gellert Mezei
Keywords
insulin resistance, mimetic, glucosamine, vanadate, hepatocytes
Access Setting
Masters Thesis-Open Access
Abstract
Insulin resistance and type II diabetes is a disease state characterized by a lack of sensitivity of insulin to provoke a proper response in insulin sensitive tissues. Currently, we utilize glucosamine to increase flux through the Hexosamine Biosynthetic Pathway (HBP) to induce an insulin resistance like state in primary rat hepatocytes. We tested the effectiveness of the insulin mimetic sodium orthovanadate to determine if it could elicit an insulin-like response under these conditions. Mixed results were obtained on the effectiveness of vanadate as an insulin mimetic in this insulin resistant model.
Recommended Citation
McPherson, Kalan, "Study of the Insulin Mimetic Sodium Orthovanadate in Glucosamine Induced Insulin Resistnace in Primary Rat Hepatocytes" (2013). Masters Theses. 130.
https://scholarworks.wmich.edu/masters_theses/130
Included in
Endocrinology, Diabetes, and Metabolism Commons, Medical Biochemistry Commons, Medicinal-Pharmaceutical Chemistry Commons