Date of Award
Master of Science
Dr. Susan R. Stapleton
Dr. David Huffman
Dr. Gellert Mezei
insulin resistance, mimetic, glucosamine, vanadate, hepatocytes
Masters Thesis-Open Access
Insulin resistance and type II diabetes is a disease state characterized by a lack of sensitivity of insulin to provoke a proper response in insulin sensitive tissues. Currently, we utilize glucosamine to increase flux through the Hexosamine Biosynthetic Pathway (HBP) to induce an insulin resistance like state in primary rat hepatocytes. We tested the effectiveness of the insulin mimetic sodium orthovanadate to determine if it could elicit an insulin-like response under these conditions. Mixed results were obtained on the effectiveness of vanadate as an insulin mimetic in this insulin resistant model.
McPherson, "Study of the Insulin Mimetic Sodium Orthovanadate in Glucosamine Induced Insulin Resistnace in Primary Rat Hepatocytes" (2013). Master's Theses. 130.