Date of Award
12-1983
Degree Name
Master of Science
Department
Biological Sciences
First Advisor
Dr. Cecil L. MeIntire
Second Advisor
Dr. Leonard Beuving
Third Advisor
Dr. Jaime Benitez
Access Setting
Masters Thesis-Open Access
Abstract
The occurrence of perinatal deaths, bony extoses, and deafness in dog kennels in certain areas of Michigan led The Upjohn Company and Western Michigan University to suspect fluoride toxicity and/or water born toxins. The present project was designed to examine the ability of excess fluoride ingestion and/or the ability of suspected water born toxins to induce histopathology in Sprague-Dawley rats. An otopathological assessment of the rat temporal bones showed no otopathology nor any changes in cochlear dimensions, however, a quantitative assessment of osteoclastic density showed a large increase in the numbers of osteoclasts of spongy bone in the high fluoride animals.
Recommended Citation
Healy, Donna Lee, "Histopathology in Rat Temporal Bones Resulting from Excess Dietary Fluoride in Conjunction with Suspected Water Born Toxins" (1983). Masters Theses. 1598.
https://scholarworks.wmich.edu/masters_theses/1598