Date of Award


Degree Name

Master of Science


Biological Sciences

First Advisor

Dr. Cecil L. MeIntire

Second Advisor

Dr. Leonard Beuving

Third Advisor

Dr. Jaime Benitez

Access Setting

Masters Thesis-Open Access


The occurrence of perinatal deaths, bony extoses, and deafness in dog kennels in certain areas of Michigan led The Upjohn Company and Western Michigan University to suspect fluoride toxicity and/or water born toxins. The present project was designed to examine the ability of excess fluoride ingestion and/or the ability of suspected water born toxins to induce histopathology in Sprague-Dawley rats. An otopathological assessment of the rat temporal bones showed no otopathology nor any changes in cochlear dimensions, however, a quantitative assessment of osteoclastic density showed a large increase in the numbers of osteoclasts of spongy bone in the high fluoride animals.

Included in

Biology Commons