Date of Award
4-1983
Degree Name
Master of Science
Department
Biological Sciences
First Advisor
Dr. Cecil L. MeIntire
Second Advisor
Dr. Leonard C. Ginsberg
Third Advisor
Dr. Jaime T. Benitez
Access Setting
Masters Thesis-Open Access
Abstract
Recent evidence suggests that a bilateral, progressive sensorineural hearing loss is associated with diabetes mellitus in humans. The microangiopathy presumedly leading to this loss seems to be similar to microvascular changes leading to this loss seems to be similar to microvascular changes leading to renal and retinal deterioration. A total of twenty-four pairs of temporal bones from two diabetic, and one non-diabetic lines of the Chinese hamster were processed and evaluated for their total auditory histopathology. Hematoxylin and eosin serial sections demonstrated a mean otopathological involvement 5.6 times greater for diabetic animals compared to non-diabetic animals. Capillary basement membrane thickening was observed in the auditory and vestibular systems 5.5 times more often for diabetics. The Chinese hamster appears to be an adequete animal model for studying the otopathological effects of the diabetic state.
Recommended Citation
Oostveen, Jo A., "Otopathology in Two Lines of the Diabetic Chinese Hamster, Cricetulus Griseus" (1983). Masters Theses. 1622.
https://scholarworks.wmich.edu/masters_theses/1622