Author

Oostveen

Date of Award

4-1983

Degree Name

Master of Science

Department

Biological Sciences

First Advisor

Dr. Cecil L. MeIntire

Second Advisor

Dr. Leonard C. Ginsberg

Third Advisor

Dr. Jaime T. Benitez

Access Setting

Masters Thesis-Open Access

Abstract

Recent evidence suggests that a bilateral, progressive sensorineural hearing loss is associated with diabetes mellitus in humans. The microangiopathy presumedly leading to this loss seems to be similar to microvascular changes leading to this loss seems to be similar to microvascular changes leading to renal and retinal deterioration. A total of twenty-four pairs of temporal bones from two diabetic, and one non-diabetic lines of the Chinese hamster were processed and evaluated for their total auditory histopathology. Hematoxylin and eosin serial sections demonstrated a mean otopathological involvement 5.6 times greater for diabetic animals compared to non-diabetic animals. Capillary basement membrane thickening was observed in the auditory and vestibular systems 5.5 times more often for diabetics. The Chinese hamster appears to be an adequete animal model for studying the otopathological effects of the diabetic state.

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