Date of Award
4-1982
Degree Name
Master of Arts
Department
Chemistry
First Advisor
Dr. Robert E. Harmon
Second Advisor
Dr. Don Iffland
Access Setting
Masters Thesis-Open Access
Abstract
Several analogues of Steffimycinone - an anthracycline antitumor antibiotic - have been prepared. Modifications were made at C-7 and C-10 of the non-aromatic A ring portion of the anthracycline nucleus. Compounds with nitrogen substituents were prepared. The synthesis of these compounds is discussed as well as their antitumor activity. The unsuccessful approaches to several other analogues are also discussed.
Recommended Citation
Elrod, David Wayne, "Analogues of Steffimycinone" (1982). Masters Theses. 1697.
https://scholarworks.wmich.edu/masters_theses/1697