Temporal Pattern of Gluconeogenesis in Diabetic and Non-Diabetic Chinese Hamsters

Author

John P. Ofenstein

Date of Award

8-1982

Degree Name

Master of Science

Department

Biological Sciences

First Advisor

Dr. Leonard J. Beuving

Second Advisor

Dr. Leonard Ginsberg

Third Advisor

Dr. Cecil Mclntire

Access Setting

Masters Thesis-Open Access

Abstract

Gluconeogenesis is a normal physiological response of an individual to low blood glucose levels by which proteins are utilized in order to synthesize new glucose. Gluconeogenic rates in diabetic and normal Chinese hamsters were measured, on four different occasions over a 24 hour period, by injecting a radio-labelled precursor (¹⁴C-lactate) into the animals. Then blood was tested for incorporation of the label into glucose. In the fed state, gluconeogenesis shows a circadian change in nondiabetic hamsters as well as in diabetic hamsters, with the diabetic hamsters showing a significantly greater gluconeogenic rate than the non-diabetic hamsters for every time point measured.

Recommended Citation

Ofenstein, John P., "Temporal Pattern of Gluconeogenesis in Diabetic and Non-Diabetic Chinese Hamsters" (1982). Masters Theses. 1717.
https://scholarworks.wmich.edu/masters_theses/1717