Date of Award


Degree Name

Master of Science


Biological Sciences

First Advisor

Dr. Leonard J. Beuving

Second Advisor

Dr. Leonard Ginsberg

Third Advisor

Dr. Cecil Mclntire

Access Setting

Masters Thesis-Open Access


Gluconeogenesis is a normal physiological response of an individual to low blood glucose levels by which proteins are utilized in order to synthesize new glucose. Gluconeogenic rates in diabetic and normal Chinese hamsters were measured, on four different occasions over a 24 hour period, by injecting a radio-labelled precursor (14C-lactate) into the animals. Then blood was tested for incorporation of the label into glucose. In the fed state, gluconeogenesis shows a circadian change in nondiabetic hamsters as well as in diabetic hamsters, with the diabetic hamsters showing a significantly greater gluconeogenic rate than the non-diabetic hamsters for every time point measured.