Date of Award
8-1982
Degree Name
Master of Science
Department
Biological Sciences
First Advisor
Dr. Cecil L. Mclntire
Second Advisor
Dr. Leonard Beuving
Third Advisor
Dr. Leonard C. Ginsberg
Access Setting
Masters Thesis-Open Access
Abstract
Ethylnitrosourea (ENU) is very strongly mutagenic, carcinogenic and teratogenic in mice. In the present study ENU was used to induce germ cell damage in the mouse testis. Mice were given single injections of vehicle, 50, 100, or 200 milligrams of ENU per kilogram of body weight and killed at various times over a fifteen week period. Microscopic examination of the testes showed that extensive killing of spermatogonial cells and therefore maturation depletion had occurred in the seminiferous tubules. The histopathology was dose dependent and the testicular weight decreased with an increasing ENU concentration.
Recommended Citation
Rodriguez, Mildred, "A Histopathological Study of the Effect of Ethylnitrosourea on HA(ICR) Mice Testes" (1982). Masters Theses. 1730.
https://scholarworks.wmich.edu/masters_theses/1730