Date of Award


Degree Name

Master of Science


Biological Sciences

First Advisor

Dr. Cecil L. Mclntire

Second Advisor

Dr. Leonard Beuving

Third Advisor

Dr. Leonard C. Ginsberg

Access Setting

Masters Thesis-Open Access


Ethylnitrosourea (ENU) is very strongly mutagenic, carcinogenic and teratogenic in mice. In the present study ENU was used to induce germ cell damage in the mouse testis. Mice were given single injections of vehicle, 50, 100, or 200 milligrams of ENU per kilogram of body weight and killed at various times over a fifteen week period. Microscopic examination of the testes showed that extensive killing of spermatogonial cells and therefore maturation depletion had occurred in the seminiferous tubules. The histopathology was dose dependent and the testicular weight decreased with an increasing ENU concentration.

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Biology Commons