Date of Award
Master of Science
Dr. Leonard J. Beuving
Dr. Leonard Ginsberg
Dr. George Gerritsen
Masters Thesis-Open Access
The objective of this study was to determine whether diabetic Chinese Hamsters maintained elevated endogenous cortisol concentrations and whether the previously reported elevation in gluconeogenesis in these diabetic animals was correlated with these cortisol concentrations.
It was found that nonketotic diabetic Chinese Hamsters maintained plasma cortisol concentrations similar to those of controls for the morning and evening time periods examined. Their rate of gluconeogenesis and absorption of injected pyruvate is much greater than that of controls in the morning. Furthermore, adrenalectomy increases gluconeogenesis and pyruvate absorption in both diabetics and normals and alleviates the difference seen in these parameters in the intact morning animals. Finally, short term cortisol therapy was unable to restore preadrenalectomy gluconeogenic values in either the diabetic or normal animals.
Woody, Charles James, "The Effects of Glucocorticoids on Gluconeogenesis in Diabetic and Normal Chinese Hamsters" (1981). Masters Theses. 1915.