Date of Award
4-1973
Degree Name
Master of Arts
Department
Biological Sciences
First Advisor
Dr. Gyula Ficsor
Second Advisor
Dr. Walter Johnson
Third Advisor
Dr. Joseph Engemann
Access Setting
Masters Thesis-Open Access
Abstract
Streptozocin-induced small colony variants of E. coli were characterized and found to have a genetic basis. Both E. coli and S. typhimurium were susceptible to the mutation causing small colonies. Small colony cell lines exhibited a greatly increased generation time and were shown to be non-motile, electron microscopy revealing a complete loss of flagella. The small colony phenotype was revertible by streptozotocin and nitrosoguanidine. The locus responsible for small colony phenotype in one strain of E. coli was found to map within a 19 minute segment of the chromosome between HfrH and HfrC.
Recommended Citation
Zimmer, David M., "Characterization of Streptozotocin Induced Small Colony Phenotypes in Bacteria" (1973). Masters Theses. 2684.
https://scholarworks.wmich.edu/masters_theses/2684