The Study of the Metal Complexes of Alpha Aminohydroxamic Acids

Author

Richard N. Nipe

Date of Award

11-1966

Degree Name

Master of Arts

Department

Chemistry

First Advisor

Dr. Robert E. Harmon

Second Advisor

Dr. Donald J. Brown

Access Setting

Masters Thesis-Open Access

Abstract

Introduction

The objectives of this investigation were to develop: 1) compounds similar to hydroxy urea, a compound known to have anti-tumor activity, 2) a method to prepare α-aminohydroxamic acids and to study the complexes of these compounds with several metal ions, 3) computer programs to determine the pK's¹ of the hydroxamic acids and the stepwise stability constants² for the ligands and several metal ions.

The values obtained for the stability constants were compared with values for the stability constants of acetohydroxamic acid and α-aminocarboxylic acids in an attempt to find which in the ligand formed bonds with the metal ions. These compounds will also be screened for anti-tumor activity and if found active, a correlation of stability constants and biological activity will be undertaken.

Recommended Citation

Nipe, Richard N., "The Study of the Metal Complexes of Alpha Aminohydroxamic Acids" (1966). Masters Theses. 4401.
https://scholarworks.wmich.edu/masters_theses/4401