Date of Award
Master of Arts
Dr. Robert E. Harmon
Dr. Donald J. Brown
Masters Thesis-Open Access
The objectives of this investigation were to develop: 1) compounds similar to hydroxy urea, a compound known to have anti-tumor activity, 2) a method to prepare α-aminohydroxamic acids and to study the complexes of these compounds with several metal ions, 3) computer programs to determine the pK's1 of the hydroxamic acids and the stepwise stability constants2 for the ligands and several metal ions.
The values obtained for the stability constants were compared with values for the stability constants of acetohydroxamic acid and α-aminocarboxylic acids in an attempt to find which in the ligand formed bonds with the metal ions. These compounds will also be screened for anti-tumor activity and if found active, a correlation of stability constants and biological activity will be undertaken.
Nipe, Richard N., "The Study of the Metal Complexes of Alpha Aminohydroxamic Acids" (1966). Masters Theses. 4401.