Date of Award
7-1963
Degree Name
Master of Arts
Department
Biological Sciences
First Advisor
Dr. Leo C. Vander Beek
Second Advisor
Dr. Jean McVay Lawrence
Third Advisor
Dr. Thane Robinson
Access Setting
Masters Thesis-Open Access
Abstract
Introduction
Goldblatt and his associates (1934) were the first to show that persistent arterial hypertension could be produced by renal ischemia. They produced renal ischemia by two procedures which involved reduction of the blood supply to one or both kidneys by means of adjustable silver clamps and removal of the non-ischemic kidney where only one kidney was made ischemic. In one procedure the clamps were placed directly on the renal arteries. The second procedure produced renal ischemia indirectly by constriction of the abdominal aorta above and below the site of the origin of both renal arteries (1939). The adjustable silver clamp devised by Goldblatt (1934) and his associated was intended for larger animals such as sheep and dogs, and clamps of smaller scale proved to be cumbersome for rats. Schaffenburg (1959) devised a simplified method for making and applying Goldblatt clips to control the constriction of the renal artery of rats and other small animals.
Recommended Citation
Medlin, Julie Jones, "The Effect of Renal Artery Constriction on the Course of Pregnancy in the Laboratory Rat" (1963). Masters Theses. 4478.
https://scholarworks.wmich.edu/masters_theses/4478