Date of Award


Degree Name

Master of Arts


Biological Sciences

First Advisor

Dr. Leo C. Vander Beek

Second Advisor

Dr. Jean McVay Lawrence

Third Advisor

Dr. Thane Robinson

Access Setting

Masters Thesis-Open Access



Goldblatt and his associates (1934) were the first to show that persistent arterial hypertension could be produced by renal ischemia. They produced renal ischemia by two procedures which involved reduction of the blood supply to one or both kidneys by means of adjustable silver clamps and removal of the non-ischemic kidney where only one kidney was made ischemic. In one procedure the clamps were placed directly on the renal arteries. The second procedure produced renal ischemia indirectly by constriction of the abdominal aorta above and below the site of the origin of both renal arteries (1939). The adjustable silver clamp devised by Goldblatt (1934) and his associated was intended for larger animals such as sheep and dogs, and clamps of smaller scale proved to be cumbersome for rats. Schaffenburg (1959) devised a simplified method for making and applying Goldblatt clips to control the constriction of the renal artery of rats and other small animals.

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Biology Commons