Date of Award
12-1994
Degree Name
Master of Science
Department
Biological Sciences
First Advisor
Dr. Leonard J. Beuving
Second Advisor
Dr. Cindy Hoorn
Third Advisor
Dr. Charles Mackenzie
Fourth Advisor
Dr. Anthony Manning
Access Setting
Masters Thesis-Open Access
Abstract
Estrogen causes an influx of eosinophils into the uterus in female rats. The diapedesis of eosinophils out of the vasculature has also been observed in allergic reactions, parasitic infections, and atopic dermatitis, and has been associated with cellular adhesion molecules (CAMs). Antibody blocking studies against ICAM-1/ LFA-1 and VCAM-1/VLA-4 have suggested that both ligand/receptor sets of CAMs are involved in the selective recruitment of eosinophils out of the vasculature. ICAM- 1 is expressed on the vascular endothelium and decreases in expression when IL-4 is introduced. VLA-4 is present on eosinophils and is suspected to allow selective migration of eosinophils out of the blood system. Uterii of immature rats treated with either diethylstilbesterol (DES) or vehicle, were labeled with monoclonal antibodies against ICAM-1 and VLA-4. ICAM-1 expression decreased in DES treated animals and VLA-4 expression was up regulated on eosinophils within the uterus. Estrogens may signal eosinophils to increase VLA-4 expression while signaling uterine vasculature to decrease ICAM-1 expression, enabling selective eosinophil migration.
Recommended Citation
Orcutt, Daniel R., "Estrogen Induced Eosinophil Migration into the August Rat Uterus is Associated with Intercellular Adhesion Molecule Expression" (1994). Masters Theses. 4531.
https://scholarworks.wmich.edu/masters_theses/4531