Date of Award
6-1997
Degree Name
Master of Arts
Department
Chemistry
First Advisor
Dr. Robert E. Harmon
Second Advisor
Dr. Ralph Steinhaus
Third Advisor
Dr. Donald Schreiber
Access Setting
Masters Thesis-Open Access
Abstract
Two different synthetic routes to poly-hydroxylated chalcones are investigated. The wittig synthesis and protection of the hydroxyl functionalities by forming the methyl ether followed by the base catalyzed Claissen-schmidt reaction and then deprotection were investigated. It was demonstrated that the protection-condensation- deprotection route was more efficient. The antiviral activity of 2,2', 4' - trihydroxychalcone against the HIV virus is also presented.
Recommended Citation
Hoff, Kiel Steven, "Synthesis of Biologically Active Substituted Chalcones" (1997). Masters Theses. 4580.
https://scholarworks.wmich.edu/masters_theses/4580