Author

Hoff

Date of Award

6-1997

Degree Name

Master of Arts

Department

Chemistry

First Advisor

Dr. Robert E. Harmon

Second Advisor

Dr. Ralph Steinhaus

Third Advisor

Dr. Donald Schreiber

Access Setting

Masters Thesis-Open Access

Abstract

Two different synthetic routes to poly-hydroxylated chalcones are investigated. The wittig synthesis and protection of the hydroxyl functionalities by forming the methyl ether followed by the base catalyzed Claissen-schmidt reaction and then deprotection were investigated. It was demonstrated that the protection-condensation- deprotection route was more efficient. The antiviral activity of 2,2', 4' - trihydroxychalcone against the HIV virus is also presented.

Included in

Chemistry Commons

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