We discuss strategies within the field to restore hearing in the context of a flat epithelia model. This could assist in avoiding the limitations of current treatment options along with the obstacles associated with cellular restoration attempts. A review of the important genes required for the development, differentiation, and long-term maintenance of the organ of Corti (OC) demonstrates that any future direction to regenerate hair cells necessitates a better understanding of the gene expression in addition to the cells present during the phalangeal scarring process and the flat epithelia environment. This understanding could be achieved through the development of a characterized flat epithelia, followed by complete regeneration of various sensory cell types in the correct location that respond appropriately to noise stimuli. Of course, this strategy would have to be modified for the different types and cellular manifestations of hearing loss. The characterization of the flat epithelia model and the context of the genes can be further manipulated for precise regeneration of a functional OC based on the cellular environment within the specific patient’s cochlea.
Sheltz-Kempf, Sydney N.
"Strategies to Restore Hearing,"
The Hilltop Review: Vol. 12:
1, Article 3.
Available at: https://scholarworks.wmich.edu/hilltopreview/vol12/iss1/3