Date of Award
8-2007
Degree Name
Master of Science
Department
Chemistry
First Advisor
Dr. Subra Muralidharan
Second Advisor
Dr. Yirong Mo
Third Advisor
Dr. Sherine Obare
Access Setting
Masters Thesis-Open Access
Abstract
The research is focused on developing nanosensors consisting of different components that are chemically linked, namely, nanoparticle, fluorescent monomer, and receptor (NMR sensors) and nanoparticle, monomer, nanomolecule, and receptor (NMNR sensors) for the sensitive and selective detection of nerve gas agents. These sensors detect the target toxins by fluorescence change which is amplified by signal transduction. Model nerve gas toxins (DCP) and (DMMP) and HCl were employed as analytes, and the nitrogen heterocyclic compounds, 5-aminoindazole and dipyrido[3,2-a:2',3'-c]phenazine (dppz) as receptors in the NMR and NNMR nanosensors. The monomers were (E)-4-(4- formylstyryl) benzoic acid (NMR sensor) and 2-mercaptosuccinic acid (NNMR sensor). The nanoparticles used were quantum dots which were Zn, Cd alloys with Zn:Cd ratios of 1:1 ZnS:CdS (NMR) and core shell quantum dots, ZnS:Mn/ZnS (NNMR). The NMR sensors (Sensor I) were more effective for the detection of DCP and HCl than the NNMR sensors (Sensor II).
Recommended Citation
Katram, Swapna, "Nitrogen Heterocyclic Compounds as Receptors in Nanosensors for Nerve Gas Agent Analogs" (2007). Masters Theses. 4253.
https://scholarworks.wmich.edu/masters_theses/4253