Swapna Katram

Date of Award


Degree Name

Master of Science



First Advisor

Dr. Subra Muralidharan

Second Advisor

Dr. Yirong Mo

Third Advisor

Dr. Sherine Obare

Access Setting

Masters Thesis-Open Access


The research is focused on developing nanosensors consisting of different components that are chemically linked, namely, nanoparticle, fluorescent monomer, and receptor (NMR sensors) and nanoparticle, monomer, nanomolecule, and receptor (NMNR sensors) for the sensitive and selective detection of nerve gas agents. These sensors detect the target toxins by fluorescence change which is amplified by signal transduction. Model nerve gas toxins (DCP) and (DMMP) and HCl were employed as analytes, and the nitrogen heterocyclic compounds, 5-aminoindazole and dipyrido[3,2-a:2',3'-c]phenazine (dppz) as receptors in the NMR and NNMR nanosensors. The monomers were (E)-4-(4- formylstyryl) benzoic acid (NMR sensor) and 2-mercaptosuccinic acid (NNMR sensor). The nanoparticles used were quantum dots which were Zn, Cd alloys with Zn:Cd ratios of 1:1 ZnS:CdS (NMR) and core shell quantum dots, ZnS:Mn/ZnS (NNMR). The NMR sensors (Sensor I) were more effective for the detection of DCP and HCl than the NNMR sensors (Sensor II).

Included in

Chemistry Commons